diff --git a/src/DebugLogger.cc b/src/DebugLogger.cc
index f95db79139..49b0205efe 100644
--- a/src/DebugLogger.cc
+++ b/src/DebugLogger.cc
@@ -115,7 +115,7 @@ void DebugLogger::EnableStreams(const char* s)
 			exit(0);
 			}
 
-		if ( strncmp(tok, "plugin-", strlen("plugin-")) == 0 )
+		if ( util::starts_with(tok, "plugin-") )
 			{
 			// Cannot verify this at this time, plugins may not
 			// have been loaded.
@@ -144,6 +144,29 @@ void DebugLogger::EnableStreams(const char* s)
 	delete[] tmp;
 	}
 
+bool DebugLogger::CheckStreams(const std::set<std::string>& plugin_names)
+	{
+	bool ok = true;
+
+	std::set<std::string> available_plugin_streams;
+	for ( const auto& p : plugin_names )
+		available_plugin_streams.insert(PluginStreamName(p));
+
+	for ( auto const& stream : enabled_streams )
+		{
+		if ( ! util::starts_with(stream, "plugin-") )
+			continue;
+
+		if ( available_plugin_streams.count(stream) == 0 )
+			{
+			reporter->Error("No plugin debug stream '%s' found", stream.c_str());
+			ok = false;
+			}
+		}
+
+	return ok;
+	}
+
 void DebugLogger::Log(DebugStream stream, const char* fmt, ...)
 	{
 	Stream* g = &streams[int(stream)];
@@ -168,8 +191,7 @@ void DebugLogger::Log(DebugStream stream, const char* fmt, ...)
 
 void DebugLogger::Log(const plugin::Plugin& plugin, const char* fmt, ...)
 	{
-	std::string tok = std::string("plugin-") + plugin.Name();
-	tok = util::strreplace(tok, "::", "-");
+	std::string tok = PluginStreamName(plugin.Name());
 
 	if ( enabled_streams.find(tok) == enabled_streams.end() )
 		return;
diff --git a/src/DebugLogger.h b/src/DebugLogger.h
index ce2aae57dc..591bfb85c4 100644
--- a/src/DebugLogger.h
+++ b/src/DebugLogger.h
@@ -11,6 +11,8 @@
 #include <set>
 #include <string>
 
+#include "zeek/util.h"
+
 #define DBG_LOG(stream, args...)                                                                   \
 	if ( ::zeek::detail::debug_logger.IsEnabled(stream) )                                          \
 	::zeek::detail::debug_logger.Log(stream, args)
@@ -84,6 +86,9 @@ public:
 	// Takes comma-seperated list of stream prefixes.
 	void EnableStreams(const char* streams);
 
+	// Check the enabled streams for invalid ones.
+	bool CheckStreams(const std::set<std::string>& plugin_names);
+
 	bool IsEnabled(DebugStream stream) const { return streams[int(stream)].enabled; }
 
 	void SetVerbose(bool arg_verbose) { verbose = arg_verbose; }
@@ -105,6 +110,11 @@ private:
 	std::set<std::string> enabled_streams;
 
 	static Stream streams[NUM_DBGS];
+
+	const std::string PluginStreamName(const std::string& plugin_name)
+		{
+		return "plugin-" + util::strreplace(plugin_name, "::", "-");
+		}
 	};
 
 extern DebugLogger debug_logger;
diff --git a/src/zeek-setup.cc b/src/zeek-setup.cc
index ca7e5333e3..53f9b781a3 100644
--- a/src/zeek-setup.cc
+++ b/src/zeek-setup.cc
@@ -847,6 +847,20 @@ SetupResult setup(int argc, char** argv, Options* zopts)
 			exit(success ? 0 : 1);
 			}
 
+#ifdef DEBUG
+		// Check debug streams. Specifically that all plugin-
+		// streams are valid now that the active plugins are known.
+		std::set<std::string> active_plugins;
+		for ( const auto p : plugin_mgr->ActivePlugins() )
+			active_plugins.insert(p->Name());
+
+		if ( ! debug_logger.CheckStreams(active_plugins) )
+			{
+			early_shutdown();
+			exit(1);
+			}
+#endif
+
 		packet_mgr->InitPostScript(options.unprocessed_output_file.value_or(""));
 		analyzer_mgr->InitPostScript();
 		file_mgr->InitPostScript();
diff --git a/testing/btest/Baseline/plugins.debug-streams/zeek.stderr b/testing/btest/Baseline/plugins.debug-streams/zeek.stderr
new file mode 100644
index 0000000000..7f6cbf9e04
--- /dev/null
+++ b/testing/btest/Baseline/plugins.debug-streams/zeek.stderr
@@ -0,0 +1,2 @@
+### BTest baseline data generated by btest-diff. Do not edit. Use "btest -U/-u" to update. Requires BTest >= 0.63.
+error in <command line>, line 3: No plugin debug stream 'plugin-zeek-http' found
diff --git a/testing/btest/plugins/debug-streams.zeek b/testing/btest/plugins/debug-streams.zeek
new file mode 100644
index 0000000000..87d60773a1
--- /dev/null
+++ b/testing/btest/plugins/debug-streams.zeek
@@ -0,0 +1,7 @@
+# This requires Zeek with debug streams support.
+# @TEST-REQUIRES: test "$(zeek-config --build_type)" = "debug"
+
+# @TEST-EXEC: zeek -B plugin-Zeek-HTTP -e 'event zeek_init() { print "zeek_init"; }' 2>zeek.stderr
+# @TEST-EXEC-FAIL: zeek -B plugin-zeek-http -e 'event zeek_init() { print "zeek_init"; }' 2>zeek.stderr
+
+# @TEST-EXEC: btest-diff zeek.stderr